Generation of a control iPS cell line (JUCGRMi006-A) with no abnormalities in Parkinson's disease-related genes

Kei-Ichi Ishikawa; Takahiro Shiga; Manabu Funayama; Nobutaka Hattori; Wado Akamatsu

doi:10.1016/j.scr.2023.103270

Generation of a control iPS cell line (JUCGRMi006-A) with no abnormalities in Parkinson's disease-related genes

Stem Cell Res. 2024 Feb:74:103270. doi: 10.1016/j.scr.2023.103270. Epub 2023 Dec 8.

Authors

Kei-Ichi Ishikawa¹, Takahiro Shiga², Manabu Funayama³, Nobutaka Hattori⁴, Wado Akamatsu²

Affiliations

¹ Center for Genomic and Regenerative Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan; Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan; Department of Research and Development for Organoids, Juntendo University School of Medicine, Tokyo, Japan. Electronic address: [email protected].
² Center for Genomic and Regenerative Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan.
³ Center for Genomic and Regenerative Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan; Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan; Research Institute for Diseases of Old Age, Juntendo University Graduate School of Medicine, Tokyo, Japan.
⁴ Center for Genomic and Regenerative Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan; Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan; Department of Research and Development for Organoids, Juntendo University School of Medicine, Tokyo, Japan; Neurodegenerative Disorders Collaborative Laboratory, RIKEN Center for Brain Science, Saitama, Japan.

PMID: 38100911
DOI: 10.1016/j.scr.2023.103270

Abstract

The appropriate control of induced pluripotent stem cells (iPSCs) is essential for studying iPSCs derived from patients with Parkinson's disease (PD). Here, we established an iPSC line from a healthy female donor. The iPSCs were pluripotent, could differentiate into three germ layers, and had normal karyotypes. We also confirmed that the iPSC line exhibited no PD-related gene abnormalities. This iPSC line will be useful for PD research.

MeSH terms

Cell Line
Female
Germ Layers / metabolism
Humans
Induced Pluripotent Stem Cells* / metabolism
Parkinson Disease* / genetics
Parkinson Disease* / metabolism