Enhancing sensitivity of triple-negative breast cancer to DNA-damaging therapy through chemical inhibition of the m6A methyltransferase METTL3

Affiliations

• ¹ Department of Anatomical, Histological, Forensic & Orthopedic Sciences, Section of Histology & Medical Embryology, Sapienza University of Rome, Rome, Italy.
• ² Department of Biology and Biotechnologies "Charles Darwin", Sapienza University of Rome, Rome, Italy.
• ³ GSTeP Organoids Research Core Facility, Fondazione Policlinico A. Gemelli Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rome, Italy.
• ⁴ Department of Drug Chemistry and Technologies, Sapienza University of Rome, Rome, Italy.
• ⁵ Pasteur Institute, Cenci-Bolognetti Foundation, Sapienza University of Rome, Rome, Italy.
• ⁶ Department of BioSciences, University of Milan, Milan, Italy.
• ⁷ Multidisciplinary Breast Center, Dipartimento Scienze della Salute della Donna e del Bambino e di Sanità Pubblica, Catholic University of the Sacred Heart, Rome, Italy.
• ⁸ Department of Neuroscience, Section of Human Anatomy, Catholic University of the Sacred Heart, Rome, Italy.
• ⁹ Oncogenomic and Epigenetic Unit, IRCCS Regina Elena National Cancer Institute, Rome, Italy.