A new synthetic route to 2- and 4-methoxyestradiols by nucleophilic substitution

S H Chen; G R Luo; X S Wu; M Chen; H M Zhao

doi:10.1016/0039-128x(86)90077-2

A new synthetic route to 2- and 4-methoxyestradiols by nucleophilic substitution

Steroids. 1986 Jan;47(1):63-6. doi: 10.1016/0039-128x(86)90077-2.

Authors

S H Chen, G R Luo, X S Wu, M Chen, H M Zhao

PMID: 3810699
DOI: 10.1016/0039-128x(86)90077-2

Abstract

A new snythetic route to 2- and 4-methoxyestradiols is described. Benzo-15-crown-5 with CuI catalyzes the specific nucleophilic substitution at the carbon atom carrying a non-activated halogen on ring A of the estradiol.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

2-Methoxyestradiol
Chemical Phenomena
Chemistry
Estradiol / analogs & derivatives*
Estradiol / chemical synthesis

Substances

4-methoxyestradiol
Estradiol
2-Methoxyestradiol