Exploring the role of ITGB6: fibrosis, cancer, and other diseases

Apoptosis. 2024 Jun;29(5-6):570-585. doi: 10.1007/s10495-023-01921-6. Epub 2023 Dec 21.

Abstract

Integrin β6 (ITGB6), a member of the integrin family of proteins, is only present in epithelial tissues and frequently associates with integrin subunit αv to form transmembrane heterodimers named integrin αvβ6. Importantly, ITGB6 determines αvβ6 expression and availability. In addition to being engaged in organ fibrosis, ITGB6 is also directly linked to the emergence of cancer, periodontitis, and several potential genetic diseases. Therefore, it is of great significance to study the molecular-biological mechanism of ITGB6, which could provide novel insights for future clinical diagnosis and therapy. This review introduces the structure, distribution, and biological function of ITGB6. This review also expounds on ITGB6-related diseases, detailing the known biological effects of ITGB6.

Keywords: Cancer; Fibrosis; Heredopathia; ITGB6; Periodontitis.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antigens, Neoplasm*
  • Fibrosis* / genetics
  • Fibrosis* / metabolism
  • Humans
  • Integrin beta Chains / genetics
  • Integrin beta Chains / metabolism
  • Integrins / genetics
  • Integrins / metabolism
  • Neoplasms* / genetics
  • Neoplasms* / metabolism
  • Neoplasms* / pathology
  • Periodontitis / genetics
  • Periodontitis / metabolism
  • Periodontitis / pathology

Substances

  • Integrin beta Chains
  • integrin beta6
  • Integrins
  • integrin alphavbeta6
  • Antigens, Neoplasm