Transformation From Atypical to Anaplastic Metastatic Meningioma: Evolutionary Turning Point Marked by Strong 18 F-FDG Avidity and Uptake Collapse From 68 GA-DOTATOC

Clin Nucl Med. 2024 Feb 1;49(2):175-176. doi: 10.1097/RLU.0000000000004985. Epub 2023 Dec 23.

Abstract

World Health Organization (WHO) grade III anaplastic meningioma is scarce. In this way, most studies compared WHO grade I and II. Otherwise, some authors are uncertain about using 18 F-FDG as a diagnostic tool to estimate the WHO grade, especially high. We report the case from a man with a grading tumor evolution from WHO grade II atypical to grade III anaplastic metastatic meningioma. This turning point was imaged using 68 Ga-DOTATOC and 18 F-FDG. Diagnostic was confirmed by histology. The case underlines the unparalleled power of molecular imaging characterized by high sensitivity staging and spectacular avidity changing relationship with grading tumor evolution.

MeSH terms

  • Fluorodeoxyglucose F18
  • Humans
  • Male
  • Meningeal Neoplasms* / diagnostic imaging
  • Meningeal Neoplasms* / pathology
  • Meningioma* / diagnostic imaging
  • Meningioma* / pathology
  • Neoplasms, Second Primary*
  • Octreotide

Substances

  • Fluorodeoxyglucose F18
  • Edotreotide
  • Octreotide