We believe it is important to underscore: The frequency and variety of the lesions, mainly within the liver but also of the biliary tract and the pancreas, which may reveal an inaugural complication of AIDS. The interest of the vascular lesions, mainly of the sinusoids as well as the various associated lesions due to pathogens (bacteria, viruses, fungi) and/or to toxic drugs. The physiopathology and histogenesis of the lesions are still obscure. Both the lesions of the hepatocytes and these of the sinusoids are poorly understood, and it is reasonable to discuss the role of various pathogens, such as viruses, peculiarly Epstein Barr and moreover LAV-HTLVIII viruses.