Impaired Neurovascular Coupling and Increased Functional Connectivity in the Frontal Cortex Predict Age-Related Cognitive Dysfunction

Affiliations

• ¹ Oklahoma Center for Geroscience and Healthy Brain Aging, University of Oklahoma Health Sciences Center, 1122 NE 13th Street, Oklahoma City, OK, 73117, USA.
• ² Vascular Cognitive Impairment and Neurodegeneration Program, Department of Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73117, USA.
• ³ Department of Physiology, Faculty of Medicine, Semmelweis University, Budapest, H-1094, Hungary.
• ⁴ International Training Program in Geroscience, Doctoral School of Basic and Translational Medicine/Department of Public Health, Semmelweis University, Budapest, H-1085, Hungary.
• ⁵ Department of Cardiology, Division of Clinical Physiology, Faculty of Medicine, University of Debrecen, Debrecen, H-4032, Hungary.
• ⁶ Department of Neurology, Dell Medical School, University of Texas at Austin, Austin, TX, 78712, USA.
• ⁷ Department of Health Promotion Sciences, College of Public Health, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA.
• ⁸ Peggy and Charles Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA.
• ⁹ Department of Neurology, Division of Stroke and Neurocritical Care, Northwestern University Feinberg School of Medicine, 303 E. Chicago Ave., Chicago, IL, 60611, USA.
• ¹⁰ Stephenson School of Biomedical Engineering, The University of Oklahoma, Tulsa, OK, 73019, USA.
• ¹¹ Department of Physical Therapy and Human Movement Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.
• ¹² Department of Rehabilitation Sciences, University of Oklahoma Health Science Center, Oklahoma City, OK, 73117, USA.
• ¹³ Arthritis & Clinical Immunology Research Program, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK, 73104, USA.
• ¹⁴ Department of Internal Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73117, USA.
• ¹⁵ Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA.
• ¹⁶ Veterans Affairs Medical Center, Oklahoma City, OK, 73104, USA.
• ¹⁷ Department of Neurology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA.
• ¹⁸ Department of Neurosurgery, Medical School, University of Pecs, Pecs, H-7623, Hungary.
• ¹⁹ Institute for Translational Medicine, Medical School, University of Pecs, Pecs, H-7624, Hungary.
• ²⁰ ELKH-PTE Clinical Neuroscience MR Research Group, Pecs, H-7624, Hungary.
• ²¹ Department of Physical Medicine and Rehabilitation, Penn State College of Medicine, 700 HMC Crescent Road, Hershey, PA, 17033, USA.