Viral RNA Is a Hub for Critical Host-Virus Interactions

Subcell Biochem. 2023:106:365-385. doi: 10.1007/978-3-031-40086-5_13.

Abstract

RNA is a central molecule in the life cycle of viruses, acting not only as messenger (m)RNA but also as a genome. Given these critical roles, it is not surprising that viral RNA is a hub for host-virus interactions. However, the interactome of viral RNAs remains largely unknown. This chapter discusses the importance of cellular RNA-binding proteins in virus infection and the emergent approaches developed to uncover and characterise them.

Keywords: Interferon-Stimulated Genes (ISGs); RNA; RNA Interactome Capture (RIC); RNA viruses; RNA-Binding Proteins (RBPs); Riboregulation.

MeSH terms

  • Host Microbial Interactions* / genetics
  • Host-Pathogen Interactions / genetics
  • RNA, Viral* / genetics
  • RNA, Viral* / metabolism
  • RNA-Binding Proteins / genetics
  • RNA-Binding Proteins / metabolism
  • Virus Replication

Substances

  • RNA, Viral
  • RNA-Binding Proteins