Structural analysis of conformational changes in the mpox virus A7 protein

Virol Sin. 2024 Apr;39(2):331-334. doi: 10.1016/j.virs.2023.12.006. Epub 2023 Dec 28.

Abstract

  1. Phospholipid-binding abilities of mpox virus A7 protein and its truncations are investigated.

  2. The structures of the N-terminal truncations of A7 protein (A7N121 and A7N137) are determined.

  3. Conformational changes of the conserved linking helix in A7 are illustrated.

  4. A structural model of the full-length A7 protein is proposed.

Publication types

  • Letter

MeSH terms

  • Models, Molecular
  • Monkeypox virus*
  • Protein Conformation*
  • Viral Proteins* / chemistry
  • Viral Proteins* / genetics

Substances

  • Viral Proteins