Large tumoral pseudoangiomatous stromal hyperplasia with ER/PR stromal negativity in a 20-year-old female: A rare case report

Somar Mansour; Seif-Aldin Abdul Rahman; Ali Kazour; Ibrahim Salama; Hussain Shmayes; Samer Rajab; Rana Issa

doi:10.1002/ccr3.8398

Large tumoral pseudoangiomatous stromal hyperplasia with ER/PR stromal negativity in a 20-year-old female: A rare case report

Clin Case Rep. 2024 Jan 2;12(1):e8398. doi: 10.1002/ccr3.8398. eCollection 2024 Jan.

Authors

Somar Mansour¹, Seif-Aldin Abdul Rahman², Ali Kazour³, Ibrahim Salama⁴, Hussain Shmayes³, Samer Rajab⁵, Rana Issa¹

Affiliations

¹ Department of Pathology Cancer Research Center, Tishreen University Hospital Latakia Syria.
² Department of Obstetrics and Gynecology Cancer Research Center, Tishreen University Hospital Latakia Syria.
³ Faculty of Medicine Tishreen University Latakia Syria.
⁴ Department of Internal Medicine Tishreen University Hospital Latakia Syria.
⁵ Department of General and Thoracic Surgery Tishreen University Hospital Latakia Syria.

Abstract

Pseudoangiomatous stromal hyperplasia (PASH) is a rare lesion of the breast stromal tissue with unknown mechanism. Hormonal stimulation of mammary myofibroblasts is the most important theory due to stromal positivity of progesterone receptor (PR) or/and estrogen receptor (ER). We report a case of PASH with stromal PR/ER negativity.

Keywords: breast tumor; case report; gigantomastia; pseudoangiomatous; stromal hyperplasia.

Publication types

Case Reports