Preparation and evaluation of blend polymer films for wound dressing using vancomycin-loaded polycaprolactone and carboxymethyl cellulose via crosslinking methods: Effect of mechanical strength, antibacterial activity, and cytotoxicity

Paweena Meedecha; Naruebodee Srisang; Komgrit Eawsakul; Tassanee Ongtanasup; Supreeda Tambunlertchai; Siwakon Sokjabok; Thatchapol Chungcharoen; Siriwan Srisang; Warunee Limmun

doi:10.1016/j.jmbbm.2023.106339

Preparation and evaluation of blend polymer films for wound dressing using vancomycin-loaded polycaprolactone and carboxymethyl cellulose via crosslinking methods: Effect of mechanical strength, antibacterial activity, and cytotoxicity

J Mech Behav Biomed Mater. 2024 Mar:151:106339. doi: 10.1016/j.jmbbm.2023.106339. Epub 2023 Dec 25.

Authors

Paweena Meedecha¹, Naruebodee Srisang¹, Komgrit Eawsakul², Tassanee Ongtanasup², Supreeda Tambunlertchai³, Siwakon Sokjabok¹, Thatchapol Chungcharoen¹, Siriwan Srisang⁴, Warunee Limmun¹

Affiliations

¹ Department of Engineering, King Mongkut's Institute of Technology Ladkrabang, Prince of Chumphon Campus, Chumphon 86160, Thailand.
² Department of Applied Thai Traditional Medicine, School of Medicine, Walailak University, Nakhon Si Thammarat 80160, Thailand.
³ National Nanotechnology Center (NANOTEC), National Science and Technology Development Agency (NSTDA), Pathum Thani 12120, Thailand.
⁴ Department of Engineering, King Mongkut's Institute of Technology Ladkrabang, Prince of Chumphon Campus, Chumphon 86160, Thailand. Electronic address: [email protected].

PMID: 38184930
DOI: 10.1016/j.jmbbm.2023.106339

Abstract

Polycaprolactone (PCL) and carboxymethyl cellulose (CMC) are two materials with beneficial properties for wound healing applications. Here, the simple preparation of PCL/CMC polymer films via the crosslinking method was demonstrated for the first time. The polymer films represented the suitable properties of liquid absorption and tensile strength to be used as a wound dressing. The blend polymer films can also load the vancomycin, which prolongs the drug release for effectiveness against S. aureus. The trifluoroethanol showed less toxicity in comparison with other crosslinking agents. This process can also be applied further in other medical devices and wound healing applications.

Keywords: Antimicrobial property; Biocompatible; Carboxymethyl cellulose; Polycaprolactone; Vancomycin.

MeSH terms

Anti-Bacterial Agents / pharmacology
Bandages
Carboxymethylcellulose Sodium*
Polyesters*
Polymers
Staphylococcus aureus
Vancomycin* / pharmacology

Substances

Vancomycin
polycaprolactone
Carboxymethylcellulose Sodium
Polymers
Anti-Bacterial Agents
Polyesters