Abstract
Two neolignan glycosides including a new one (1), along with seven iridoid glycosides (3 - 9) and nine flavonoid glycosides (10 - 18), were isolated from the leaves of Vaccinium bracteatum. Their structures were established mainly on the basis of 1D/2D NMR and ESIMS analyses, as well as comparison to known compounds in the literature. The structure of 1 with absolute stereochemistry was also confirmed by chemical degradation and ECD calculation. Selective compounds showed antiradical activity against ABTS and/or DPPH. Moreover, several isolates also suppressed the production of ROS in RAW264.7 cells and exerted neuroprotective effect toward PC12 cells.
Keywords:
Ericaceae; Vaccinium bracteatum; antioxidant activity; cell protective activity; flavonoid glycoside; iridoid glycoside; lignan glycoside.
MeSH terms
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Animals
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Flavonoids* / chemistry
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Flavonoids* / isolation & purification
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Flavonoids* / pharmacology
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Glycosides* / chemistry
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Glycosides* / isolation & purification
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Glycosides* / pharmacology
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Iridoid Glycosides / chemistry
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Iridoid Glycosides / isolation & purification
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Iridoid Glycosides / pharmacology
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Iridoids / chemistry
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Iridoids / isolation & purification
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Iridoids / pharmacology
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Lignans* / chemistry
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Lignans* / isolation & purification
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Lignans* / pharmacology
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Mice
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Molecular Structure
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Neuroprotective Agents / chemistry
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Neuroprotective Agents / isolation & purification
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Neuroprotective Agents / pharmacology
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PC12 Cells
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Picrates / pharmacology
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Plant Leaves* / chemistry
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RAW 264.7 Cells
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Rats
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Reactive Oxygen Species
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Vaccinium / chemistry
Substances
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Flavonoids
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Glycosides
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Lignans
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Neuroprotective Agents
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Iridoids
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Iridoid Glycosides
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Reactive Oxygen Species
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Picrates