Changes in Inflammatory Cytokines After Chronic Hepatitis C Treatment Among People Living With HIV

Hamidreza Karimi-Sari; Damani A Piggott; Eileen P Scully; Kathleen Ward; Catherine G Sutcliffe; Mark Sulkowski; Oluwaseun Falade-Nwulia

doi:10.1093/ofid/ofad623

Changes in Inflammatory Cytokines After Chronic Hepatitis C Treatment Among People Living With HIV

Open Forum Infect Dis. 2024 Jan 4;11(1):ofad623. doi: 10.1093/ofid/ofad623. eCollection 2024 Jan.

Authors

Hamidreza Karimi-Sari¹, Damani A Piggott^{1

2}, Eileen P Scully¹, Kathleen Ward¹, Catherine G Sutcliffe^{2

3}, Mark Sulkowski¹, Oluwaseun Falade-Nwulia¹

Affiliations

¹ Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
² Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
³ Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.

Abstract

We aimed to evaluate the effect of hepatitis C virus cure on serum inflammatory markers among people with HIV. Among 127 people with HIV, serum alanine aminotransferase, soluble tumor necrosis factor receptor 1, and inflammatory index score were significantly lower at the 24-week time point in patients who achieved sustained virologic response as compared with those who did not.

Keywords: HIV; chronic hepatitis C; direct-acting antivirals; mediators of inflammation.

Grants and funding

K23 DA041294/DA/NIDA NIH HHS/United States