Experiences and outcomes of fertility testing in male adolescents with sickle cell disease

Pediatr Blood Cancer. 2024 Apr;71(4):e30848. doi: 10.1002/pbc.30848. Epub 2024 Jan 10.

Abstract

Adult males with sickle cell disease (SCD) may have abnormal semen parameters, raising the concern that SCD and/or treatments may impact fertility. Yet, studies that include adolescents are lacking. To determine if fertility testing is feasible in male adolescents with SCD, and to explore their experiences and outcomes of fertility testing, 33 adolescents who completed a web-based SCD reproductive health education program were offered a free semen analysis. Five (15%) obtained testing and each had abnormalities. Barriers to testing included lack of time and transportation and discomfort. Findings highlight the need for larger, longitudinal studies using innovative testing approaches.

Keywords: fertility testing; male adolescents; sickle cell disease.

MeSH terms

  • Adolescent
  • Adult
  • Anemia, Sickle Cell* / therapy
  • Fertility
  • Humans
  • Longitudinal Studies
  • Male