Cancer-Associated Fibroblasts: Major Co-Conspirators in Tumor Development

Cancers (Basel). 2024 Jan 2;16(1):211. doi: 10.3390/cancers16010211.

Shubhangi Singh^{1

2}, Ajay P Singh^{2

3

4}, Ranjana Mitra⁵

¹ Department of International Studies (Global Health), College of Arts and Sciences, University of South Alabama, Mobile, AL 36688, USA.
² Cancer Biology Program, Mitchell Cancer Institute, University of South Alabama, Mobile, AL 36604, USA.
³ Department of Pathology, Frederick P. Whiddon College of Medicine, University of South Alabama, Mobile, AL 36617, USA.
⁴ Department of Biochemistry and Molecular Biology, Frederick P. Whiddon College of Medicine, University of South Alabama, Mobile, AL 36688, USA.
⁵ Biomedical Sciences, College of Medicine, Roseman University of Health Sciences, Las Vegas, NV 89135, USA.

Abstract

The tumor microenvironment (TME) is a critical determinant of tumor progression, metastasis, and therapeutic outcomes [...].