Short tandem repeats genotyping of gestational choriocarcinoma - our experiences

Taiwan J Obstet Gynecol. 2024 Jan;63(1):73-76. doi: 10.1016/j.tjog.2023.10.004.

Abstract

Objective: This short communication demonstrates how short tandem repeat genotyping can identify the origin of gestational choriocarcinoma.

Materials and methods: The origin of gestational choriocarcinoma in our three cases was determined using the short tandem repeats genotyping technique, which involved quantitative fluorescent PCR and fragmentation analysis.

Results: In Case 1 despite no medical history of molar pregnancy, DNA analysis indicated that the choriocarcinoma originated from a homozygous complete hydatidiform mole. We conclude, that the patient's complete abortion 10 years prior to the choriocarcinoma diagnosis was an undiagnosed complete hydatidiform mole. In Case 2 and Case 3 the clinically presumed origin of choriocarcinoma was confirmed.

Conclusion: Determining the origin of choriocarcinoma is essential for clinical application, as it affects the FIGO scoring system for gestational trophoblastic neoplasia, which determines the patient's prognosis and treatment approach.

Keywords: Choriocarcinoma; DNA; Gestational trophoblastic disease; Microsatellite repeats.

MeSH terms

  • Choriocarcinoma* / diagnosis
  • Choriocarcinoma* / genetics
  • Choriocarcinoma* / pathology
  • Female
  • Genotype
  • Gestational Trophoblastic Disease* / diagnosis
  • Gestational Trophoblastic Disease* / genetics
  • Humans
  • Hydatidiform Mole* / diagnosis
  • Hydatidiform Mole* / genetics
  • Hydatidiform Mole* / pathology
  • Microsatellite Repeats / genetics
  • Pregnancy
  • Uterine Neoplasms* / diagnosis
  • Uterine Neoplasms* / genetics
  • Uterine Neoplasms* / pathology