SYNTHETIC APPROACHES TO 4,8-DIMETHYL-4'- (N-PYRIDINIUMMETHYL)- 4',5'-DIHYDROPSORALENS AND THEIR ACTIVITY AGAINST PAM 212 KERATINOCYTES

Marilyn S Whittemore; Ned D Heindel; Christophe D Guillon; Thomas E McNeel; Robert D Rapp; Thomas M Mariano; Diane E Heck; Jeffrey D Laskin

doi:10.3987/com-01-9197

SYNTHETIC APPROACHES TO 4,8-DIMETHYL-4'- (N-PYRIDINIUMMETHYL)- 4',5'-DIHYDROPSORALENS AND THEIR ACTIVITY AGAINST PAM 212 KERATINOCYTES

Heterocycles. 2001;55(6):1081-1093. doi: 10.3987/com-01-9197.

Authors

Marilyn S Whittemore^{1

2}, Ned D Heindel², Christophe D Guillon², Thomas E McNeel¹, Robert D Rapp³, Thomas M Mariano⁴, Diane E Heck⁵, Jeffrey D Laskin⁴

Affiliations

¹ Department of Chemistry, Lehigh University, 6 East Packer Avenue, Bethlehem, PA 18015, U. S. A.
² Buckman Laboratories, 1256 North McLean Blvd., Memphis, TN 38108, U. S. A.
³ Department of Chemistry, Albright College, P.O. Box 15234, Reading, PA 19612-5234, U. S. A.
⁴ Department of Environmental and Community Medicine, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, NJ 08854, U. S. A.
⁵ Department of Pharmacology and Toxicology, Rutgers University, Piscataway, NJ 08854, U. S. A.

Abstract

Synthetic approaches to novel 4,8-dimethyl-4'-halomethyl-4',5'-dihydropsoralens as synthetic precursors to 4,8-dimethyl-4'-(N-pyridiniummethyl)-4',5'-dihydropsoralens are described. The compounds are potential therapeutic agents for improved psoralen ultraviolet radiation therapy with reduced mutagenicity.

Grants and funding

P30 ES005022/ES/NIEHS NIH HHS/United States