Symptomatic creatine phosphokinase elevation in a Crohn's disease patient caused by upadacitinib

Anna Schuitema; Suzanne I Anjie; Agnies M van Eeghen; Sander W Tas; Mark Löwenberg

doi:10.1002/ccr3.8227

Symptomatic creatine phosphokinase elevation in a Crohn's disease patient caused by upadacitinib

Clin Case Rep. 2024 Jan 19;12(1):e8227. doi: 10.1002/ccr3.8227. eCollection 2024 Jan.

Authors

Anna Schuitema¹, Suzanne I Anjie¹, Agnies M van Eeghen^{2

3}, Sander W Tas⁴, Mark Löwenberg¹

Affiliations

¹ Department of Gastroenterology and Hepatology Amsterdam UMC, Location Academic Medical Center, University of Amsterdam Amsterdam The Netherlands.
² 's Heeren Loo Amersfoort The Netherlands.
³ Department of Pediatrics, Emma Center for Personalized Medicine Amsterdam UMC, Location Academic Medical Center, University of Amsterdam Amsterdam The Netherlands.
⁴ Department of Rheumatology Amsterdam UMC, Location Academic Medical Center, University of Amsterdam Amsterdam The Netherlands.

Abstract

We present a Crohn's disease patient receiving high dose upadacitinib treatment with elevated CPK levels and myopathy, and provide the reader with practical tips on stopping and restarting upadacitinib, emphasizing the need for adequate monitoring.

Keywords: CPK elevation; Crohn's disease; myopathy; upadacitinib.

Publication types

Case Reports