Genetically divergent Francisella philomiragia associated with septic arthritis, Montevideo, Uruguay

Nadia Riera; Cecilia Salazar; Bernardina Rivera; Antonio Galiana; Rosario Durán; María Magdalena Portela; Virginia Antelo; Beatriz Pi; Óscar González; Gregorio Iraola

doi:10.1016/j.nmni.2023.101210

Genetically divergent Francisella philomiragia associated with septic arthritis, Montevideo, Uruguay

New Microbes New Infect. 2023 Dec 14:57:101210. doi: 10.1016/j.nmni.2023.101210. eCollection 2024 Mar.

Authors

Nadia Riera^{1

2}, Cecilia Salazar^{1

2}, Bernardina Rivera^{2

3}, Antonio Galiana⁴, Rosario Durán³, María Magdalena Portela³, Virginia Antelo⁵, Beatriz Pi⁵, Óscar González⁵, Gregorio Iraola^{1

2

6}

Affiliations

¹ Microbial Genomics Laboratory, Institut Pasteur Montevideo, Montevideo, Uruguay.
² Center for Innovation in Epidemiological Surveillance, Institut Pasteur Montevideo, Montevideo, Uruguay.
³ Analytical Biochemistry and Proteomics Unit, Instituto de Investigaciones Biológicas Clemente Estable and Institut Pasteur Montevideo, Montevideo, Uruguay.
⁴ Hospital Maciel, Montevideo, Uruguay.
⁵ Asistencial Médica de Maldonado, Maldonado, Uruguay.
⁶ Wellcome Sanger Institute, Cambridgeshire, United Kingdom.

Abstract

Here we report a case of septic arthritis associated with a genetically divergent Francisella philomiragia strain in a patient with chronic rheumatoid arthritis and Adult-onset Still's disease (AOSD) in Maldonado, Uruguay. In this study mass spectrometry together with whole-genome sequencing using Oxford Nanopore technology allowed for the correct identification of the etiologic agent.