Pathology and Clinical Significance of Inflammatory Bowel Disease-Associated Colorectal Dysplastic Lesions

Noam Harpaz; Steven H Itzkowitz

doi:10.1016/j.gtc.2023.09.005

Pathology and Clinical Significance of Inflammatory Bowel Disease-Associated Colorectal Dysplastic Lesions

Gastroenterol Clin North Am. 2024 Mar;53(1):133-154. doi: 10.1016/j.gtc.2023.09.005. Epub 2023 Dec 22.

Authors

Noam Harpaz¹, Steven H Itzkowitz²

Affiliations

¹ Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai; Department of Medicine, Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, Annenberg Building 5-12L, 1468 Madison Avenue, New York, NY 10029, USA. Electronic address: [email protected].
² Department of Medicine, Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, Annenberg Building 5-12L, 1468 Madison Avenue, New York, NY 10029, USA.

PMID: 38280745
DOI: 10.1016/j.gtc.2023.09.005

Abstract

Timely diagnosis and effective management of colorectal dysplasia play a vital role in preventing mortality from colorectal cancer in patients with chronic inflammatory bowel disease. This review provides a contemporary overview of the pathologic and endoscopic classification of dysplasia in inflammatory bowel disease, their roles in determining surveillance and management algorithms, and emerging diagnostic and therapeutic approaches that might further enhance patient management.

Keywords: Colorectal cancer; Crohn disease; Dysplasia; Inflammatory bowel disease; Ulcerative colitis.

Publication types

Review

MeSH terms

Chronic Disease
Clinical Relevance
Colitis, Ulcerative* / pathology
Colonoscopy
Colorectal Neoplasms* / diagnosis
Colorectal Neoplasms* / etiology
Colorectal Neoplasms* / pathology
Humans
Hyperplasia
Inflammatory Bowel Diseases* / complications
Inflammatory Bowel Diseases* / diagnosis