Organ-specific aging in the plasma proteome predicts disease

Trends Mol Med. 2024 May;30(5):423-424. doi: 10.1016/j.molmed.2024.01.005. Epub 2024 Jan 31.

Abstract

In their recent Nature paper, Oh et al. use 4979 plasma proteins collected across multiple cohorts, publicly available gene expression data, and machine learning models to identify 11 organ-specific aging scores that are linked to organ-specific disease and mortality risk, including heart failure, cognitive decline, and Alzheimer's disease.

MeSH terms

  • Aging* / blood
  • Alzheimer Disease / blood
  • Alzheimer Disease / genetics
  • Alzheimer Disease / metabolism
  • Biomarkers / blood
  • Blood Proteins* / genetics
  • Blood Proteins* / metabolism
  • Heart Failure / blood
  • Heart Failure / genetics
  • Humans
  • Machine Learning
  • Organ Specificity
  • Proteome* / analysis

Substances

  • Proteome
  • Blood Proteins
  • Biomarkers