Impact of adenomyosis on pregnancy outcomes: a retrospective consecutive cohort study

Eur Rev Med Pharmacol Sci. 2024 Jan;28(2):577-583. doi: 10.26355/eurrev_202401_35055.

Abstract

Objective: This retrospective study explored the potential connection between adenomyosis and pregnancy outcomes.

Patients and methods: A study included data from a total of 1,208 pregnancies. The adenomyosis group included 334 pregnant women with adenomyosis, and women in the control group (n=874) had uncomplicated pregnancies. Data on pregnancy complications and maternal and neonatal outcomes were compared.

Results: The incidence of gestational hypertension, gestational diabetes, and placenta previa was higher in the adenomyosis group compared to the control group (p<0.05). Adenomyosis was linked to a higher risk of postpartum hemorrhage (1,000-1,500 ml) but a lower risk of premature rupture of membranes (PROM) (p<0.05). Diagnosis of adenomyosis correlated with increased incidence of low fetal weight (20.3% vs. 21.3%, p<0.05) and a low APGAR score at 1 min (p<0.05).

Conclusions: Adenomyosis correlated with a higher incidence of gestational hypertension, placenta previa, and gestational diabetes. At the same time, adenomyosis correlated with a significantly lower incidence of PROM compared to uncomplicated pregnancy. There was a significant increase in the incidence of postpartum hemorrhage and a higher risk of low fetal weight and lower APGAR score at 1 min in pregnancies with adenomyosis.

MeSH terms

  • Adenomyosis* / complications
  • Adenomyosis* / epidemiology
  • Cohort Studies
  • Diabetes, Gestational* / epidemiology
  • Female
  • Fetal Weight
  • Humans
  • Hypertension, Pregnancy-Induced*
  • Infant, Newborn
  • Placenta Previa* / epidemiology
  • Postpartum Hemorrhage*
  • Pregnancy
  • Pregnancy Outcome / epidemiology
  • Retrospective Studies