Gut microb-aging and its relevance to frailty aging

Guillaume Le Cosquer; Nathalie Vergnolle; Jean-Paul Motta

doi:10.1016/j.micinf.2024.105309

Gut microb-aging and its relevance to frailty aging

Microbes Infect. 2024 Mar-Apr;26(3):105309. doi: 10.1016/j.micinf.2024.105309. Epub 2024 Feb 4.

Authors

Guillaume Le Cosquer¹, Nathalie Vergnolle², Jean-Paul Motta³

Affiliations

¹ Institute of Digestive Health Research, IRSD, Toulouse University, INSERM U1220, INRAe, ENVT, UPS, 31300 Toulouse, France; Department of Gastroenterology and Pancreatology, Toulouse University Hospital, Toulouse Paul Sabatier University, 31059 Toulouse, France.
² Institute of Digestive Health Research, IRSD, Toulouse University, INSERM U1220, INRAe, ENVT, UPS, 31300 Toulouse, France; Department of Physiology & Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
³ Institute of Digestive Health Research, IRSD, Toulouse University, INSERM U1220, INRAe, ENVT, UPS, 31300 Toulouse, France. Electronic address: [email protected].

PMID: 38316374
DOI: 10.1016/j.micinf.2024.105309

Abstract

This review explores 'microb-aging' in the gut and its potential link to frailty aging. We explore this connection through alterations in microbiota's taxonomy and metabolism, as well as with concepts of ecological resilience, pathobionts emergence, and biogeography. We examine microb-aging in interconnected body organs, emphasizing the bidirectional relationship with 'inflammaging'. Finally, we discuss how targeting microb-aging could improve screening, diagnostic, and therapeutic approaches in geriatrics.

Keywords: Aging and frailty; Geroprotector; Geroscience; Inflammaging; Microb-aging.

Publication types

Review

MeSH terms

Aging*
Frailty*
Gastrointestinal Microbiome*
Humans