Much has changed since March 2020, when the World Health Organization declared Covid-19 a pandemic and clinicians around the world began desperately searching for therapies that could help afflicted patients. Barely 2.5 years after SARS-CoV-2 was discovered, we have solid evidence for the efficacy and safety of repurposed and novel agents for pre- and postexposure prophylaxis and for mild and severe disease, not to mention highly effective vaccines.