Prevalence of delayed initiation of rabies postexposure prophylaxis and factors influencing it among animal bite victims from Eastern Uttar Pradesh, India

Trans R Soc Trop Med Hyg. 2024 Jun 4;118(6):399-404. doi: 10.1093/trstmh/trae002.

Abstract

Background: In a rabies-endemic country like India, every animal bite is potentially taken as rabid exposure and timely and appropriate postexposure prophylaxis (PEP) is crucial as rabies is an almost 100% fatal disease.

Methods: A retrospective record-based study was conducted at an anti-rabies clinic (ARC) in Eastern Uttar Pradesh, India. Data of the animal bite victims attending the ARC for PEP from January to December 2022 were extracted from the records. A semistructured questionnaire was used for collecting information regarding the interval between exposure and the initiation of anti-rabies PEP, age, gender, residence, the bite site on the body, category of exposure and other risk factors associated with the delay in PEP.

Results: Most of the victims were male (67.6%), from an urban background (61.3%) and aged up to 20 y (43.9%). Out of the 222 victims, 62 (27.9%) had delayed initiation of PEP (>48 h after exposure). Factors found to be significantly associated with delayed initiation of PEP were residence (p=0.01), age (p=0.04) and the type of biting animal (p=0.002).

Conclusions: Delayed initiation of PEP is common among animal bite victims in this region of India, although PEP is affordable. Educational programmes and awareness-raising campaigns for timely administration of PEP should be a priority, especially targeting rural residents, those aged<18 y and those bitten by animals other than dogs.

Keywords: animal bite; delay; postexposure prophylaxis; rabies; vaccine-preventable disease.

MeSH terms

  • Adolescent
  • Adult
  • Animals
  • Bites and Stings* / epidemiology
  • Child
  • Child, Preschool
  • Dogs
  • Female
  • Humans
  • India / epidemiology
  • Male
  • Middle Aged
  • Post-Exposure Prophylaxis* / statistics & numerical data
  • Prevalence
  • Rabies Vaccines / administration & dosage
  • Rabies* / epidemiology
  • Rabies* / prevention & control
  • Retrospective Studies
  • Risk Factors
  • Surveys and Questionnaires
  • Time Factors
  • Time-to-Treatment / statistics & numerical data
  • Young Adult

Substances

  • Rabies Vaccines