Study design: This paper presents a description of a conceptual framework and methodology that is applicable to the manuscripts that comprise this focus issue.
Objectives: Our goal is to present a conceptual framework which is relied upon to better understand the processes through which surgeons make therapeutic decisions around how to treat thoracolumbar burst fractures (TL) fractures.
Methods: We will describe the methodology used in the AO Spine TL A3/4 Study prospective observational study and how the radiographs collected for this study were utilized to study the relationships between various variables that factor into surgeon decision making.
Results: With 22 expert spine trauma surgeons analyzing the acute CT scans of 183 patients with TL fractures we were able to perform pairwise analyses, look at reliability and correlations between responses and develop frequency tables, and regression models to assess the relationships and interactions between variables. We also used machine learning to develop decision trees.
Conclusions: This paper outlines the overall methodological elements that are common to the subsequent papers in this focus issue.
Keywords: burst fractures; methodology; thoracolumbar; treatment recommendations.