The OMERACT whole-body MRI scoring system for inflammation in peripheral joints and entheses (WIPE) in spondyloarthritis - reference image atlas for the knee region

Mikkel Østergaard; Marie Wetterslev; Anna Ef Hadsbjerg; Walter P Maksymowych; Iris Eshed; Lennart Jans; Yasser Emad; Susanne J Pedersen; Maria S Stoenoiu; Paul Bird; Violaine Foltz; Ashish J Mathew; Joel Paschke; Philippe Carron; Gabriele De Marco; Helena Marzo-Ortega; Signe Møller-Bisgaard; Philip G Conaghan; Robert Gw Lambert

doi:10.1016/j.semarthrit.2024.152384

The OMERACT whole-body MRI scoring system for inflammation in peripheral joints and entheses (WIPE) in spondyloarthritis - reference image atlas for the knee region

Semin Arthritis Rheum. 2024 Apr:65:152384. doi: 10.1016/j.semarthrit.2024.152384. Epub 2024 Feb 3.

Authors

Mikkel Østergaard¹, Marie Wetterslev², Anna Ef Hadsbjerg³, Walter P Maksymowych⁴, Iris Eshed⁵, Lennart Jans⁶, Yasser Emad⁷, Susanne J Pedersen², Maria S Stoenoiu⁸, Paul Bird⁹, Violaine Foltz¹⁰, Ashish J Mathew¹¹, Joel Paschke¹², Philippe Carron¹³, Gabriele De Marco¹⁴, Helena Marzo-Ortega¹⁴, Signe Møller-Bisgaard¹⁵, Philip G Conaghan¹⁴, Robert Gw Lambert¹⁶

Affiliations

¹ Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre for Head and Orthopaedics, Rigshospitalet, Glostrup, Denmark; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark. Electronic address: [email protected].
² Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre for Head and Orthopaedics, Rigshospitalet, Glostrup, Denmark.
³ Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre for Head and Orthopaedics, Rigshospitalet, Glostrup, Denmark; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
⁴ Department of Medicine, University of Alberta, Edmonton, Alberta, Canada; CARE Arthritis, Edmonton, Alberta, Canada.
⁵ Department of Diagnostic Imaging, Sheba Medical Center, Affiliated to the School of Medicine, Tel-Aviv University, Israel.
⁶ Department of Radiology, Ghent University Hospital, Ghent, Belgium.
⁷ Department of Rheumatology, Faculty of Medicine, Cairo University, Egypt.
⁸ Department of Rheumatology, Cliniques Universitaires Saint-Luc, Institut de Recherche Experimentale et Clinique, Université Catholique de Louvain, Bruxelles, Belgium.
⁹ Division of Medicine, University of New South Wales, Sydney, Australia.
¹⁰ Department of Rheumatology, Sorbonne University, APHP, Pitié-Salpètrière Hospital, Paris, France.
¹¹ Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre for Head and Orthopaedics, Rigshospitalet, Glostrup, Denmark; Department of Clinical Immunology & Rheumatology, Christian Medical College, Vellore, India.
¹² CARE Arthritis, Edmonton, Alberta, Canada.
¹³ Department of Rheumatology, Ghent University Hospital, Ghent, Belgium; VIB Inflammation Research Centre, Ghent University, Ghent, Belgium.
¹⁴ Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, UK; NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds, UK.
¹⁵ Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre for Head and Orthopaedics, Rigshospitalet, Glostrup, Denmark; Department of Rheumatology, Slagelse Hospital, Slagelse, Denmark.
¹⁶ Department of Radiology and Diagnostic Imaging, University of Alberta, Edmonton, Alberta, Canada.

PMID: 38325053
DOI: 10.1016/j.semarthrit.2024.152384

Abstract

Objective: To develop a reference image atlas for the Outcome Measures in Rheumatology whole-body MRI scoring system for inflammation in peripheral joints and entheses (OMERACT MRI-WIPE) of the knee region.

Methods: Image examples of each pathology, location and grade, were collected and discussed at web-based, interactive meetings within the OMERACT MRI in Arthritis Working Group. Subsequently, reference images were selected by consensus.

Results: Reference images for each grade, pathology and location are depicted, along with definitions, reader rules and recommended MRI-sequences.

Conclusion: The atlas guides scoring whole-body MRIs for inflammation in joints and entheses of the knee region according to MRI-WIPE methodology in clinical trials and cohorts.

Keywords: Arthritis; Enthesitis; Knee; MRI-WIPE; OMERACT; Spondyloarthritis; Whole-body MRI.

MeSH terms

Humans
Inflammation* / diagnostic imaging
Magnetic Resonance Imaging / methods
Reproducibility of Results
Severity of Illness Index
Spondylarthritis* / diagnostic imaging
Whole Body Imaging / methods