Brain connectivity changes to fast versus slow dopamine increases

Neuropsychopharmacology. 2024 May;49(6):924-932. doi: 10.1038/s41386-024-01803-8. Epub 2024 Feb 7.

Abstract

The rewarding effects of stimulant drugs such as methylphenidate (MP) depend crucially on how fast they raise dopamine in the brain. Yet how the rate of drug-induced dopamine increases impacts brain network communication remains unresolved. We manipulated route of MP administration to generate fast versus slow dopamine increases. We hypothesized that fast versus slow dopamine increases would result in a differential pattern of global brain connectivity (GBC) in association with regional levels of dopamine D1 receptors, which are critical for drug reward. Twenty healthy adults received MP intravenously (0.5 mg/kg; fast dopamine increases) and orally (60 mg; slow dopamine increases) during simultaneous [11C]raclopride PET-fMRI scans (double-blind, placebo-controlled). We tested how GBC was temporally associated with slow and fast dopamine increases on a minute-to-minute basis. Connectivity patterns were strikingly different for slow versus fast dopamine increases, and whole-brain spatial patterns were negatively correlated with one another (rho = -0.54, pspin < 0.001). GBC showed "fast>slow" associations in dorsal prefrontal cortex, insula, posterior thalamus and brainstem, caudate and precuneus; and "slow>fast" associations in ventral striatum, orbitofrontal cortex, and frontopolar cortex (pFDR < 0.05). "Fast>slow" GBC patterns showed significant spatial correspondence with D1 receptor availability (estimated via normative maps of [11C]SCH23390 binding; rho = 0.22, pspin < 0.05). Further, hippocampal GBC to fast dopamine increases was significantly negatively correlated with self-reported 'high' ratings to intravenous MP across individuals (r(19) = -0.68, pbonferroni = 0.015). Different routes of MP administration produce divergent patterns of brain connectivity. Fast dopamine increases are uniquely associated with connectivity patterns that have relevance for the subjective experience of drug reward.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, N.I.H., Extramural
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Brain Mapping
  • Brain* / diagnostic imaging
  • Brain* / drug effects
  • Brain* / metabolism
  • Central Nervous System Stimulants / administration & dosage
  • Central Nervous System Stimulants / pharmacology
  • Dopamine Antagonists / administration & dosage
  • Dopamine Antagonists / pharmacology
  • Dopamine* / metabolism
  • Double-Blind Method
  • Female
  • Humans
  • Magnetic Resonance Imaging*
  • Male
  • Methylphenidate* / administration & dosage
  • Methylphenidate* / pharmacology
  • Neural Pathways / diagnostic imaging
  • Neural Pathways / drug effects
  • Positron-Emission Tomography*
  • Raclopride* / pharmacology
  • Receptors, Dopamine D1 / metabolism
  • Young Adult

Substances

  • Dopamine
  • Methylphenidate
  • Raclopride
  • Central Nervous System Stimulants
  • Receptors, Dopamine D1
  • Dopamine Antagonists