INPP4B ensures that ILC1s and NK cells set up a productive home office

Zi Yan Chen; Arthur Mortha

doi:10.1084/jem.20232375

INPP4B ensures that ILC1s and NK cells set up a productive home office

J Exp Med. 2024 Mar 4;221(3):e20232375. doi: 10.1084/jem.20232375. Epub 2024 Feb 8.

Authors

Zi Yan Chen¹, Arthur Mortha¹

Affiliation

¹ Department of Immunology, University of Toronto, Toronto, Canada.

Abstract

In this issue of JEM, Peng et al. (https://doi.org/10.1084/jem.20230124) identify inositol polyphosphate 4-phosphatase type II (encoded by Inpp4b) as an important enzyme for tissue-resident ILC1 and NK cell survival, signal transduction, and anti-tumor immunity.

MeSH terms

Cell Survival
Killer Cells, Natural*
Phosphoric Monoester Hydrolases*
Signal Transduction

Substances

phosphatidylinositol-3,4-bisphosphate 4-phosphatase
Phosphoric Monoester Hydrolases