Higher baseline heart rate variability in CCHS patients with progestin-associated recovery of hypercapnic ventilatory response

Respir Res. 2024 Feb 9;25(1):87. doi: 10.1186/s12931-023-02625-w.

Abstract

After a fortuitous observation of two cases of chemosensitivity recovery in women with congenital central hypoventilation syndrome (CCHS) who took desogestrel, we aimed to evaluate the ventilatory response to hypercapnia of five CCHS patients with or without treatment consisting of desogestrel (DESO) or levonorgestrel (LEVO). Only two patients became responsive to hypercapnia under treatment, according to their basal vagal heart rate variability. These results suggest that heart rate variability may be promising tool to discriminate patients susceptible to become responsive to hypercapnia under DESO-LEVO treatment.Clinical Trials Identifier NCT01243697.

Keywords: Autonomic nervous system; Desogestrel; Heart rate variability; Hypoventilation syndrome.

Publication types

  • Letter

MeSH terms

  • Desogestrel / therapeutic use
  • Female
  • Heart Rate
  • Homeodomain Proteins / therapeutic use
  • Humans
  • Hypercapnia / diagnosis
  • Hypercapnia / drug therapy
  • Hypoventilation / congenital*
  • Progestins* / therapeutic use
  • Sleep Apnea, Central*

Substances

  • Progestins
  • Desogestrel
  • Homeodomain Proteins

Supplementary concepts

  • Congenital central hypoventilation syndrome

Associated data

  • ClinicalTrials.gov/NCT01243697