Tixagevimab-cilgavimab (AZD7442) for the treatment of patients hospitalized with COVID-19 (DisCoVeRy): A phase 3, randomized, double-blind, placebo-controlled trial

Maya Hites; Clément R Massonnaud; Eva Larranaga Lapique; Drifa Belhadi; Simon Jamard; François Goehringer; François Danion; Jean Reignier; Nathalie de Castro; Denis Garot; Karine Lacombe; Violaine Tolsma; Emmanuel Faure; Denis Malvy; Thérèse Staub; Johan Courjon; France Cazenave-Roblot; Anne Ma Dyrhol Riise; Paul Leturnier; Guillaume Martin-Blondel; Claire Roger; Karolina Akinosoglou; Vincent Le Moing; Lionel Piroth; Pierre Sellier; Xavier Lescure; Marius Trøseid; Philippe Clevenbergh; Olav Dalgard; Sébastien Gallien; Marie Gousseff; Paul Loubet; Fanny Vardon-Bounes; Clotilde Visée; Leila Belkhir; Élisabeth Botelho-Nevers; André Cabié; Anastasia Kotanidou; Fanny Lanternier; Elisabeth Rouveix-Nordon; Susana Silva; Guillaume Thiery; Pascal Poignard; Guislaine Carcelain; Alpha Diallo; Noémie Mercier; Vida Terzic; Maude Bouscambert-Duchamp; Alexandre Gaymard; Mary-Anne Trabaud; Grégory Destras; Laurence Josset; Nicolas Billard; Thi-Hong-Lien Han; Jérémie Guedj; Sandrine Couffin-Cadiergues; Aline Dechanet; Christelle Delmas; Hélène Esperou; Claire Fougerou-Leurent; Soizic Le Mestre; Anabelle Métois; Marion Noret; Isabelle Bally; Sebastián Dergan-Dylon; Sarah Tubiana; Ouifiya Kalif; Nathalie Bergaud; Benjamin Leveau; Joe Eustace; Richard Greil; Edit Hajdu; Monika Halanova; Jose-Artur Paiva; Anna Piekarska; Jesus Rodriguez Baño; Kristian Tonby; Milan Trojánek; Sotirios Tsiodras; Serhat Unal; Charles Burdet; Dominique Costagliola; Yazdan Yazdanpanah; Nathan Peiffer-Smadja; France Mentré; Florence Ader; DisCoVeRy study group

doi:10.1016/j.jinf.2024.106120

Tixagevimab-cilgavimab (AZD7442) for the treatment of patients hospitalized with COVID-19 (DisCoVeRy): A phase 3, randomized, double-blind, placebo-controlled trial

J Infect. 2024 Mar;88(3):106120. doi: 10.1016/j.jinf.2024.106120. Epub 2024 Feb 16.

Authors

Maya Hites¹, Clément R Massonnaud², Eva Larranaga Lapique³, Drifa Belhadi², Simon Jamard⁴, François Goehringer⁵, François Danion⁶, Jean Reignier⁷, Nathalie de Castro⁸, Denis Garot⁹, Karine Lacombe¹⁰, Violaine Tolsma¹¹, Emmanuel Faure¹², Denis Malvy¹³, Thérèse Staub¹⁴, Johan Courjon¹⁵, France Cazenave-Roblot¹⁶, Anne Ma Dyrhol Riise¹⁷, Paul Leturnier¹⁸, Guillaume Martin-Blondel¹⁹, Claire Roger²⁰, Karolina Akinosoglou²¹, Vincent Le Moing²², Lionel Piroth²³, Pierre Sellier²⁴, Xavier Lescure²⁵, Marius Trøseid²⁶, Philippe Clevenbergh²⁷, Olav Dalgard²⁸, Sébastien Gallien²⁹, Marie Gousseff³⁰, Paul Loubet³¹, Fanny Vardon-Bounes³², Clotilde Visée³³, Leila Belkhir³⁴, Élisabeth Botelho-Nevers³⁵, André Cabié³⁶, Anastasia Kotanidou³⁷, Fanny Lanternier³⁸, Elisabeth Rouveix-Nordon³⁹, Susana Silva⁴⁰, Guillaume Thiery⁴¹, Pascal Poignard⁴², Guislaine Carcelain⁴³, Alpha Diallo⁴⁴, Noémie Mercier⁴⁴, Vida Terzic⁴⁴, Maude Bouscambert-Duchamp⁴⁵, Alexandre Gaymard⁴⁵, Mary-Anne Trabaud⁴⁶, Grégory Destras⁴⁷, Laurence Josset⁴⁷, Nicolas Billard⁴⁸, Thi-Hong-Lien Han⁴⁸, Jérémie Guedj⁴⁹, Sandrine Couffin-Cadiergues⁵⁰, Aline Dechanet⁵¹, Christelle Delmas⁵⁰, Hélène Esperou⁵⁰, Claire Fougerou-Leurent⁵², Soizic Le Mestre⁴⁴, Anabelle Métois⁵¹, Marion Noret⁵³, Isabelle Bally⁵⁴, Sebastián Dergan-Dylon⁵⁴, Sarah Tubiana⁵⁵, Ouifiya Kalif⁵⁶, Nathalie Bergaud⁵⁷, Benjamin Leveau⁵⁷, Joe Eustace⁵⁸, Richard Greil⁵⁹, Edit Hajdu⁶⁰, Monika Halanova⁶¹, Jose-Artur Paiva⁶², Anna Piekarska⁶³, Jesus Rodriguez Baño⁶⁴, Kristian Tonby¹⁷, Milan Trojánek⁶⁵, Sotirios Tsiodras⁶⁶, Serhat Unal⁶⁷, Charles Burdet², Dominique Costagliola⁶⁸, Yazdan Yazdanpanah²⁵, Nathan Peiffer-Smadja⁶⁹, France Mentré², Florence Ader⁷⁰; DisCoVeRy study group⁷⁰

Affiliations

¹ Clinic of Infectious Diseases, Hôpital Universitaire de Bruxelles (HUB), Université Libre de Bruxelles, Brussels, Belgium. Electronic address: [email protected].
² Université Paris Cité, Inserm, IAME, F-75018 Paris, France; AP-HP, Hôpital Bichat, Département d'Épidémiologie, Biostatistique et Recherche Clinique, F-75018 Paris, France.
³ Clinic of Infectious Diseases, Hôpital Universitaire de Bruxelles (HUB), Université Libre de Bruxelles, Brussels, Belgium.
⁴ Service de Maladies Infectieuses Et Tropicales (SMIT), Centre Hospitalier Universitaire de Tours, 37044 Tours, France.
⁵ Université de Lorraine, CHRU de Nancy, Service des Maladies Infectieuses et Tropicales, F-54000 Nancy, France.
⁶ Hôpitaux Universitaires de Strasbourg, Département de maladies infectieuses et tropicales, F-67091 Strasbourg, France.
⁷ CHU de Nantes, Service de Médecine Intensive et Réanimation, Université de Nantes, F-44093 Nantes, France.
⁸ Département des Maladies Infectieuses et Tropicales, GH Saint-Louis/Lariboisière-Fernand Widal, Université de Paris Cité, INSERM U 944, Paris, France.
⁹ CHRU Tours, Service de Médecine Intensive Réanimation, F-37044 Tours, France.
¹⁰ Sorbonne Université, Inserm, Institut Pierre-Louis d'Épidémiologie et de Santé Publique, F-75013 Paris, France; APHP, Hôpital Saint-Antoine, Service de maladies infectieuses et tropicales, F-75012 Paris, France.
¹¹ Centre Hospitalier Annecy Genevois, Service des Maladies Infectieuses et Tropicales, F-74374 Annecy, France.
¹² Université de Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019 - UMR 9017 - CIIL - Center for Infection and Immunity of Lille, F-59000 Lille, France.
¹³ Department of Infectious Diseases and Tropical Medicine, CHU Bordeaux, Bordeaux, France.
¹⁴ Centre hospitalier de Luxembourg, Service des maladies infectieuses, L-1210 Luxembourg, Luxembourg.
¹⁵ Université Côte d'Azur, CHU Nice, Nice, France, Infectious Disease Unit, Nice, France.
¹⁶ Département des Maladies Infectieuses et Tropicales, CHU de Poitiers, INSERM U1070, Poitiers, France.
¹⁷ Department of Infectious Diseases, Oslo University Hospital, 0424 Oslo, Norway.
¹⁸ Department of Infectious Diseases, Hôtel-Dieu University Hospital, University Hospital of Nantes, Nantes, France.
¹⁹ CHU de Toulouse, Service des maladies infectieuses et Tropicales, F-31320 Toulouse, France; Institut Toulousain des Maladies Infectieuses et Inflammatoires (Infinity) INSERM UMR1291 - CNRS UMR5051 - Université Toulouse III, F-31320 Toulouse, France.
²⁰ Department of Anesthesiology, Critical Care Pain, and Emergency Medicine, Nimes University Hospital, Nimes, France.
²¹ Department of Internal Medicine and Infectious Diseases, University General Hospital of Patras, Patras, Greece.
²² CHU de Montpellier, Service des Maladies Infectieuses et Tropicales, F-34295 Montpellier, France.
²³ CHU de Dijon, Département de Maladies Infectieuses, F-21000, Dijon, France; Université Bourgogne Franche-Comté, CIC 1432, INSERM, F-21000, Dijon, France.
²⁴ Infectious Diseases Department, Lariboisière Hospital, AP-HP, Paris, France.
²⁵ Université Paris Cité, Inserm, IAME, F-75018 Paris, France; AP-HP, Hôpital Bichat, Service de Maladies Infectieuses et Tropicales, F-75018 Paris, France.
²⁶ Research Institute of Internal Medicine, Division of Surgery, Inflammatory Diseases and Transplantation, Oslo University Hospital Rikshospitalet, Oslo, Norway.
²⁷ Infectious Diseases Clinic, CHU Brugmann, ULB, Brussels, Belgium.
²⁸ Department of Infectious Diseases, Division of Medicine, Akershus University Hospital, Lørenskog, Norway; Institute for Clinical Medicine, University of Oslo, Oslo, Norway.
²⁹ APHP, Hôpital Henri Mondor, Département de maladies infectieuses, F-94000 Créteil, France; INSERM U955, Team 16, IMRB Créteil, Créteil, France.
³⁰ Maladies infectieuses, Centre Hospitalier Bretagne-Atlantique, Vannes, France.
³¹ Infectious and Tropical Diseases Department, Nimes University Hospital, Nimes, France; VBIC, INSERM U1047, University of Montpellier, Nimes, France.
³² CHU de Toulouse, Département d'anesthésie et de soins intensifs, F-31300 Toulouse, France; Université Toulouse 3 Paul Sabatier, Inserm U1297, F-31300 Toulouse, France.
³³ Department of Infectious Disease, Centre Hospitalier Régional Mons-Hainaut/Groupe Jolimont, Mons Belgium/Groupe Helora, Mons, Belgium.
³⁴ Department of Internal Medicine and Infectious Diseases, Cliniques universitaires Saint-Luc, Brussels, Belgium.
³⁵ CHU de Saint-Etienne, Service d'Infectiologie, F-42055 Saint-Etienne, France; Université Jean Monnet, Université Claude Bernard Lyon 1, GIMAP, CIRI, INSERM U1111, CNRS UMR5308, ENS Lyon, F-42023 Saint-Etienne, France; CIC 1408, INSERM, F, 42055 Saint-Etienne, France.
³⁶ PCCEI, Univ Montpellier, Univ Antilles, Inserm, EFS, F-34394 Montpellier, France; CHU de Martinique, Service des maladies infectieuses et tropicales, Inserm CIC1424, F-97200 Fort de France, France.
³⁷ First Department of Critical Care Medicine and Pulmonary Services, Evangelismos Hospital, National and Kapodistrian University of Athens Medical School, 45-47 Ipsilantou Street, 10676 Athens, Greece.
³⁸ Infectious Diseases Unit, Necker-Enfants Malades University Hospital, AP-HP, Paris, France.
³⁹ AP-HP, Hôpital Ambroise-Paré, Service de Maladies Infectieuses et Tropicales, Boulogne-Billancourt, France.
⁴⁰ EPIUnit - Instituto de Saúde Pública, Universidade do Porto, Rua das Taipas, no 135, 4050-600 Porto, Portugal.
⁴¹ CHU Saint-Etienne, Hopital Nord, Medical Intensive Care Unit, Saint-Priest-En-Jarez, France.
⁴² Groupe de Recherche en Infectiologie Clinique CIC-1406, Inserm - CHUGA - Université Grenoble Alpes, Grenoble, France; Univ. Grenoble Alpes, CEA, CNRS, Institut de Biologie Structurale (IBS), Grenoble, France; Laboratoire de Virologie, Center Hospitalier Universitaire Grenoble-Alpes, Grenoble, France.
⁴³ Immunology Department, Robert Debré Hospital, Assistance Publique Hôpitaux de Paris, Paris, France; Université Paris Cité, INSERM U976, Paris, France.
⁴⁴ ANRS | Maladies Infectieuses Emergentes, Paris, France.
⁴⁵ Hospices Civils de Lyon, Laboratoire de Virologie, Institut des Agents Infectieux de Lyon, Centre National de Référence des virus respiratoires France Sud, F-69317 Lyon, France; Université Claude Bernard Lyon 1, Virpath, CIRI, INSERM U1111, CNRS UMR5308, ENS Lyon, F-69372 Lyon, France.
⁴⁶ Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Lyon, France.
⁴⁷ Hospices Civils de Lyon, Laboratoire de Virologie, Institut des Agents Infectieux de Lyon, Centre National de Référence des virus respiratoires France Sud, F-69317 Lyon, France.
⁴⁸ AP-HP, Hôpital Bichat, Département d'Épidémiologie, Biostatistique et Recherche Clinique, F-75018 Paris, France.
⁴⁹ Université Paris Cité, Inserm, IAME, F-75018 Paris, France.
⁵⁰ Institut de santé publique, Pôle recherche clinique, INSERM, Paris, France.
⁵¹ AP-HP, Hôpital Bichat, Unité de recherche clinique, F-75018 Paris, France.
⁵² CHU de Rennes, Université Rennes 1, Inserm CIC 1414, F-35000 Rennes, France.
⁵³ Renarci, Réseau National De Recherche Clinique En Infectiologie, Paris, France.
⁵⁴ Univ. Grenoble Alpes, CEA, CNRS, Institut de Biologie Structurale (IBS), Grenoble, France.
⁵⁵ Université Paris Cité, Inserm, IAME, F-75018 Paris, France; AP-HP, Hôpital Bichat, Centre de ressources biologiques, F-75018 Paris, France.
⁵⁶ AP-HP, Hôpital Bichat, Centre de ressources biologiques, F-75018 Paris, France.
⁵⁷ Hospices Civils de Lyon, Lyon, France.
⁵⁸ University College Cork, Cork, Ireland.
⁵⁹ Department of Internal Medicine III with Haematology, Medical Oncology, Haemostaseology, Infectiology and Rheumatology, Oncologic Center, Salzburg Cancer Research Institute - Laboratory for Immunological and Molecular Cancer Research (SCRI-LIMCR), Paracelsus Medical University Salzburg, 5020 Salzburg, Austria; Cancer Cluster Salzburg, 5020 Salzburg, Austria; AGMT, 5020 Salzburg, Austria.
⁶⁰ Department of Internal Medicine Infectiology Unit, Albert Szent-Györgyi Health Centre, University of Szeged, Állomás Street 1-3, 6725 Szeged, Hungary.
⁶¹ LF UPJŠ - Pavol Jozef Šafárik University in Košice Faculty of Medicine, Košice, Slovakia.
⁶² Centro Hospitalar São João, Emergency and Intensive Care Department, Porto, Portugal; Universidade do Porto, Faculty of Medicine, Porto, Portugal.
⁶³ Department of Infectious Diseases and Hepatology, Medical University of Łódź, Łódź, Poland.
⁶⁴ Infectious Diseases and Microbiology Division, Hospital Universitario Virgen Macarena, Sevilla, Spain.
⁶⁵ Department of Infectious Diseases, University Hospital Bulovka, Budínova 2, 180 81, Prague, Czech Republic.
⁶⁶ Fourth Department of Internal Medicine, Attikon University Hospital, Athens Medical School, National and Kapodistrian University of Athens, 12462 Athens, Greece.
⁶⁷ Department of Infectious Diseases, Hacettepe University Faculty of Medicine, Ankara, Turkey.
⁶⁸ Sorbonne Université, Inserm, Institut Pierre-Louis d'Épidémiologie et de Santé Publique, F-75013 Paris, France.
⁶⁹ Université Paris Cité, Inserm, IAME, F-75018 Paris, France; AP-HP, Hôpital Bichat, Service de Maladies Infectieuses et Tropicales, F-75018 Paris, France; National Institute for Health Research, Health Protection Research Unit in Healthcare Associated Infections and Antimicrobial Resistance, Imperial College London, London, UK.
⁷⁰ Hospices Civils de Lyon, Hôpital de la Croix-Rousse, Département des Maladies Infectieuses et Tropicales, F-69004 Lyon, France; Université Claude Bernard Lyon 1, CIRI, INSERM U1111, CNRS UMR5308, ENS Lyon, F-69372 Lyon, France.

PMID: 38367705
DOI: 10.1016/j.jinf.2024.106120

No abstract available

Publication types

Letter

MeSH terms

Antibodies, Monoclonal
Antibodies, Neutralizing*
COVID-19*
Clinical Trials, Phase III as Topic
Drug Combinations
Humans
Randomized Controlled Trials as Topic

Substances

Antibodies, Monoclonal
Antibodies, Neutralizing
cilgavimab
cilgavimab and tixagevimab drug combination
Drug Combinations
tixagevimab