Abstract
Renal cell carcinoma is uncommon in children and must be distinguished from the more common Wilms' tumor. Here, we present two cases of renal cell carcinoma in children both of whom presented with hematuria. Accurate diagnosis is essential in order to differentiate it from epithelial predominant Wilms' tumor which has vastly different prognosis and treatment. Immunohistochemistry for TFE3 is useful in establishing the diagnosis.
Copyright © 2023 Copyright: © 2023 Indian Journal of Pathology and Microbiology.
MeSH terms
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Basic Helix-Loop-Helix Leucine Zipper Transcription Factors* / genetics
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Carcinoma, Renal Cell* / diagnosis
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Carcinoma, Renal Cell* / genetics
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Carcinoma, Renal Cell* / pathology
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Child
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Child, Preschool
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Diagnosis, Differential
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Female
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Hematuria / etiology
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Humans
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Immunohistochemistry
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Kidney Neoplasms* / diagnosis
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Kidney Neoplasms* / genetics
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Kidney Neoplasms* / pathology
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Male
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Translocation, Genetic*
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Wilms Tumor / diagnosis
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Wilms Tumor / pathology
Substances
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Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
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TFE3 protein, human