Kluyvera georgiana Bacteremia Due to Acute Cholangitis: A Report of the First Known Case and a Literature Review

Intern Med. 2024 Oct 1;63(19):2689-2693. doi: 10.2169/internalmedicine.3036-23. Epub 2024 Feb 26.

Abstract

We herein present the first known case of bacteremia caused by Kluyvera georgiana in a 67-year-old female undergoing chemotherapy for recurrent pancreatic cancer. The patient underwent choledochojejunotomy and thereafter developed ascending cholangitis. The diagnosis of K. georgiana was confirmed using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. A literature review of Kluyvera spp. infections indicated potential risk factors including an underlying malignancy and immunosuppression. Although Kluyvera spp. infections are typically sensitive to antibiotics, multidrug resistance is possible. This case highlights the importance of the early diagnosis and treatment of K. georgiana and its associated risk factors.

Keywords: Kluyvera georgiana; bacteremia; cholangitis.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Acute Disease
  • Aged
  • Anti-Bacterial Agents / therapeutic use
  • Bacteremia* / complications
  • Bacteremia* / diagnosis
  • Bacteremia* / drug therapy
  • Bacteremia* / microbiology
  • Cholangitis* / complications
  • Cholangitis* / diagnosis
  • Cholangitis* / microbiology
  • Enterobacteriaceae Infections / complications
  • Enterobacteriaceae Infections / diagnosis
  • Enterobacteriaceae Infections / drug therapy
  • Female
  • Humans
  • Kluyvera* / isolation & purification
  • Pancreatic Neoplasms / complications
  • Pancreatic Neoplasms / diagnosis

Substances

  • Anti-Bacterial Agents