Identification of cuproptosis-related lncRNAs with the significance in prognosis and immunotherapy of oral squamous cell carcinoma

Han Gong; Zhaolong Liu; Chunhui Yuan; Ying Luo; Yuhan Chen; Junyi Zhang; Yiteng Cui; Bin Zeng; Jing Liu; Hui Li; Zhiyuan Deng

doi:10.1016/j.compbiomed.2024.108198

Identification of cuproptosis-related lncRNAs with the significance in prognosis and immunotherapy of oral squamous cell carcinoma

Comput Biol Med. 2024 Mar:171:108198. doi: 10.1016/j.compbiomed.2024.108198. Epub 2024 Feb 21.

Authors

Han Gong¹, Zhaolong Liu², Chunhui Yuan³, Ying Luo², Yuhan Chen², Junyi Zhang², Yiteng Cui², Bin Zeng⁴, Jing Liu⁵, Hui Li⁶, Zhiyuan Deng⁷

Affiliations

¹ Department of Dermatology, Hunan Engineering Research Center of Skin Health and Disease, Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China; Molecular Biology Research Center and Center for Medical Genetics, School of Life Sciences, Central South University, Changsha, Hunan, China.
² Hunan Key Laboratory of Oral Health Research, Department of Oral and Maxillofacial Surgery, Xiangya Stomatological Hospital & Xiangya School of Stomatology, Central South University, Changsha, China.
³ Department of Dermatology, Hunan Engineering Research Center of Skin Health and Disease, Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
⁴ School of Stomatology, Changsha Medical University, Changsha, Hunan, China.
⁵ Molecular Biology Research Center and Center for Medical Genetics, School of Life Sciences, Central South University, Changsha, Hunan, China.
⁶ Department of Dermatology, Hunan Engineering Research Center of Skin Health and Disease, Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China; Molecular Biology Research Center and Center for Medical Genetics, School of Life Sciences, Central South University, Changsha, Hunan, China; National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology, Central South University, Changsha, Hunan, 410008, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China. Electronic address: [email protected].
⁷ Department of Dermatology, Hunan Engineering Research Center of Skin Health and Disease, Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China; Hunan Key Laboratory of Oral Health Research, Department of Oral and Maxillofacial Surgery, Xiangya Stomatological Hospital & Xiangya School of Stomatology, Central South University, Changsha, China; School of Stomatology, Changsha Medical University, Changsha, Hunan, China. Electronic address: [email protected].

PMID: 38417385
DOI: 10.1016/j.compbiomed.2024.108198

Abstract

Cuproptosis, a recently characterized programmed cell death mechanism, has emerged as a potential contributor to tumorigenesis, metastasis, and immune modulation. Long non-coding RNAs (lncRNAs) have demonstrated diverse regulatory roles in cancer and hold promise as biomarkers. However, the involvement and prognostic significance of cuproptosis-related lncRNAs (CRLs) in oral squamous cell carcinoma (OSCC) remain poorly understood. Based on TCGA-OSCC data, we integrated single-sample gene set enrichment analysis (ssGSEA), the LASSO algorithm, and the tumor immune dysfunction and exclusion (TIDE) algorithm. We identified 11 CRLs through differential expression, Spearman correlation, and univariate Cox regression analyses. Two distinct CRL-related subtypes were unveiled, delineating divergent survival patterns, tumor microenvironments (TME), and mutation profiles. A robust CRL-based signature (including AC107027.3, AC008011.2, MYOSLID, AC005785.1, AC019080.5, AC020558.2, AC025265.1, FAM27E3, and LINC02367) prognosticated OSCC outcomes, immunotherapy responses, and anti-tumor strategies. Superior predictive power compared to other lncRNA models was demonstrated. Functional assessments confirmed the influence of FAM27E3, LINC02367, and MYOSLID knockdown on OSCC cell behaviors. Remarkably, the CRLs-based signature maintained stability across OSCC patient subgroups, underscoring its clinical potential for survival prediction. This study elucidates CRLs' roles in TME of OSCC and establishes a potential signature for precision therapy.

Keywords: Cuproptosis; Immunotherapy; Oral squamous cell carcinoma; Prognosis; Tumor microenvironment; lncRNA.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Apoptosis
Carcinoma, Squamous Cell* / genetics
Carcinoma, Squamous Cell* / therapy
Head and Neck Neoplasms*
Humans
Immunotherapy
Mouth Neoplasms* / genetics
Mouth Neoplasms* / therapy
RNA, Long Noncoding* / genetics
Squamous Cell Carcinoma of Head and Neck / genetics
Squamous Cell Carcinoma of Head and Neck / therapy
Tumor Microenvironment / genetics

Substances

RNA, Long Noncoding