Influence of FOXP3 single-nucleotide polymorphism after allogeneic hematopoietic stem cell transplantation

Int J Hematol. 2024 May;119(5):583-591. doi: 10.1007/s12185-024-03726-y. Epub 2024 Feb 28.

Abstract

The impact of FOXP3 single-nucleotide polymorphisms (SNP) on clinical outcomes after allogeneic hematopoietic stem cell transplantation (allo-HSCT) remains poorly understood. We investigated the relationship between a FOXP3 SNP (rs3761548) and clinical outcomes in 91 patients with hematological malignancies after allo-HSCT. Multivariate analysis showed that risk of severe chronic graft-versus-host disease (cGVHD) was significantly higher in patients with the FOXP3-3279C/A or FOXP3-3279A/A genotype than those with the FOXP3-3279C/C genotype [hazard ratio (HR), 2.69; 95% confidence interval (CI) 1.14-6.31; p = 0.023]. Therefore, FOXP3 at SNP rs3761548 can be a useful marker for predicting the occurrence of severe cGVHD.

Keywords: FOXP3; Allogeneic hematopoietic stem cell transplantation; Graft-versus-host disease; Polymorphism.

MeSH terms

  • Adult
  • Aged
  • Female
  • Forkhead Transcription Factors* / genetics
  • Genotype
  • Graft vs Host Disease* / etiology
  • Graft vs Host Disease* / genetics
  • Hematologic Neoplasms* / genetics
  • Hematologic Neoplasms* / therapy
  • Hematopoietic Stem Cell Transplantation*
  • Humans
  • Male
  • Middle Aged
  • Polymorphism, Single Nucleotide*
  • Transplantation, Homologous*
  • Young Adult

Substances

  • Forkhead Transcription Factors
  • FOXP3 protein, human