Peroxisome-based metabolic engineering for biomanufacturing and agriculture

Shuyan Song; Cuifang Ye; Yijun Jin; Huaxin Dai; Jianping Hu; Jiazhang Lian; Ronghui Pan

doi:10.1016/j.tibtech.2024.02.005

Peroxisome-based metabolic engineering for biomanufacturing and agriculture

Trends Biotechnol. 2024 Sep;42(9):1161-1176. doi: 10.1016/j.tibtech.2024.02.005. Epub 2024 Feb 28.

Authors

Shuyan Song¹, Cuifang Ye¹, Yijun Jin¹, Huaxin Dai², Jianping Hu³, Jiazhang Lian⁴, Ronghui Pan⁵

Affiliations

¹ State Key Laboratory of Rice Biology and Breeding, College of Chemical and Biological Engineering, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou 310058, Zhejiang, China; ZJU-Hangzhou Global Scientific and Technological Innovation Center, Zhejiang University, Hangzhou 311215, Zhejiang, China.
² Beijing Life Science Academy, Changping 102209, Beijing, China.
³ Michigan State University-Department of Energy Plant Research Laboratory and Plant Biology Department, Michigan State University, East Lansing, MI 48824, USA.
⁴ State Key Laboratory of Rice Biology and Breeding, College of Chemical and Biological Engineering, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou 310058, Zhejiang, China; ZJU-Hangzhou Global Scientific and Technological Innovation Center, Zhejiang University, Hangzhou 311215, Zhejiang, China. Electronic address: [email protected].
⁵ State Key Laboratory of Rice Biology and Breeding, College of Chemical and Biological Engineering, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou 310058, Zhejiang, China; ZJU-Hangzhou Global Scientific and Technological Innovation Center, Zhejiang University, Hangzhou 311215, Zhejiang, China. Electronic address: [email protected].

PMID: 38423802
DOI: 10.1016/j.tibtech.2024.02.005

Abstract

Subcellular compartmentalization of metabolic pathways plays a crucial role in metabolic engineering. The peroxisome has emerged as a highly valuable and promising compartment for organelle engineering, particularly in the fields of biological manufacturing and agriculture. In this review, we summarize the remarkable achievements in peroxisome engineering in yeast, the industrially popular biomanufacturing chassis host, to produce various biocompounds. We also review progress in plant peroxisome engineering, a field that has already exhibited high potential in both biomanufacturing and agriculture. Moreover, we outline various experimentally validated strategies to improve the efficiency of engineered pathways in peroxisomes, as well as prospects of peroxisome engineering.

Keywords: metabolic engineering; peroxisome; plant; subcellular compartmentalization; synthetic biology; yeast.

Publication types

Review

MeSH terms

Agriculture* / methods
Metabolic Engineering* / methods
Metabolic Networks and Pathways / genetics
Peroxisomes* / metabolism
Plants / genetics
Plants / metabolism
Saccharomyces cerevisiae / genetics
Saccharomyces cerevisiae / metabolism