Relationship Between Hepatitis C Infection and Treatment Status and Coronavirus Disease 2019-Related Hospitalizations in Georgia

J Infect Dis. 2024 Sep 23;230(3):e694-e699. doi: 10.1093/infdis/jiae103.

Abstract

Background: The aim of this study was to evaluate the impact of hepatitis C virus (HCV) infection and treatment status on coronavirus disease 2019 (COVID-19)-related hospitalizations in Georgia.

Methods: We analyzed 2020-2021 Georgian health registry data for COVID-19-positive individuals and categorized the data by HCV infection and treatment status. Logistic regression was used to assess the strengths of the associations.

Results: Treated individuals with HCV had lower odds of COVID-19-related hospitalization compared to anti-HCV-negative individuals, while untreated HCV-viremic and anti-HCV-positive nonviremic individuals had higher odds.

Conclusions: HCV treatment prior to COVID-19 infection was associated with lower odds of COVID-19-related hospitalization, highlighting the benefits of HCV management in the context of the pandemic.

Keywords: COVID-19; Georgia; direct-acting antivirals; hepatitis C virus; registry study.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Antiviral Agents / therapeutic use
  • COVID-19* / epidemiology
  • COVID-19* / therapy
  • Female
  • Georgia (Republic) / epidemiology
  • Georgia / epidemiology
  • Hepacivirus
  • Hepatitis C* / drug therapy
  • Hepatitis C* / epidemiology
  • Hospitalization* / statistics & numerical data
  • Humans
  • Male
  • Middle Aged
  • SARS-CoV-2*
  • Young Adult

Substances

  • Antiviral Agents