A tissue-silicone integrated simulator for right ventricular pulsatile circulation with severe functional tricuspid regurgitation

Jumpei Takada; Hayato Morimura; Kohei Hamada; Yusei Okamoto; Shiho Mineta; Yusuke Tsuboko; Kaoru Hattori; Kiyotaka Iwasaki

doi:10.1038/s41598-024-55058-w

A tissue-silicone integrated simulator for right ventricular pulsatile circulation with severe functional tricuspid regurgitation

Sci Rep. 2024 Mar 1;14(1):5120. doi: 10.1038/s41598-024-55058-w.

Authors

Jumpei Takada^{1

2}, Hayato Morimura^{3

4}, Kohei Hamada², Yusei Okamoto⁵, Shiho Mineta², Yusuke Tsuboko⁴, Kaoru Hattori^{2

6}, Kiyotaka Iwasaki^{7

8

9

10

11

12}

Affiliations

¹ Department of Modern Mechanical Engineering, School of Creative Science and Engineering, Waseda University, Tokyo, Japan.
² Department of Integrative Bioscience and Biomedical Engineering, Graduate School of Advanced Science and Engineering, Waseda University, Tokyo, Japan.
³ Cooperative Major in Advanced Biomedical Sciences, Joint Graduate School of Tokyo Women's Medical University and Waseda University, Waseda University, Tokyo, Japan.
⁴ Waseda Research Institute for Science and Engineering, Waseda University, Tokyo, Japan.
⁵ Department of Modern Mechanical Engineering, Graduate School of Creative Science and Engineering, Waseda University, Tokyo, Japan.
⁶ Institute for Medical Regulatory Science, Waseda University, Tokyo, Japan.
⁷ Department of Modern Mechanical Engineering, School of Creative Science and Engineering, Waseda University, Tokyo, Japan. [email protected].
⁸ Department of Integrative Bioscience and Biomedical Engineering, Graduate School of Advanced Science and Engineering, Waseda University, Tokyo, Japan. [email protected].
⁹ Cooperative Major in Advanced Biomedical Sciences, Joint Graduate School of Tokyo Women's Medical University and Waseda University, Waseda University, Tokyo, Japan. [email protected].
¹⁰ Waseda Research Institute for Science and Engineering, Waseda University, Tokyo, Japan. [email protected].
¹¹ Department of Modern Mechanical Engineering, Graduate School of Creative Science and Engineering, Waseda University, Tokyo, Japan. [email protected].
¹² Institute for Medical Regulatory Science, Waseda University, Tokyo, Japan. [email protected].

Abstract

There is a great demand for development of a functional tricuspid regurgitation (FTR) model for accelerating development and preclinical study of tricuspid interventional repair devices. This study aimed to develop a severe FTR model by creating a tissue-silicone integrated right ventricular pulsatile circulatory simulator. The simulator incorporates the porcine tricuspid annulus, valve leaflets, chordae tendineae, papillary muscles, and right ventricular wall as one continuous piece of tissue, thereby preserving essential anatomical relationships of the tricuspid valve (TV) complex. We dilated the TV annulus with collagenolytic enzymes under applying stepwise dilation, and successfully achieved a severe FTR model with a regurgitant volume of 45 ± 9 mL/beat and a flow jet area of 15.8 ± 2.3 cm² (n = 6). Compared to a normal model, the severe FTR model exhibited a larger annular circumference (133.1 ± 8.2 mm vs. 115.7 ± 5.5 mm; p = 0.009) and lower coaptation height (6.6 ± 1.0 mm vs. 17.7 ± 1.3 mm; p = 0.003). Following the De-Vega annular augmentation procedure to the severe FTR model, a significant reduction in regurgitant volume and flow jet area were observed. This severe FTR model may open new avenues for the development and evaluation of transcatheter TV devices.

MeSH terms

Animals
Chordae Tendineae
Heart Ventricles
Swine
Tricuspid Valve
Tricuspid Valve Insufficiency* / surgery

Grants and funding

JP22mk0101179/Japan Agency for Medical Research and Development