The relationship between severe hypertensive diseases of pregnancy and moderate-severe bronchopulmonary dysplasia

J Perinatol. 2024 Jul;44(7):935-940. doi: 10.1038/s41372-024-01910-w. Epub 2024 Mar 2.

Abstract

Objective: Determine the association between severe hypertensive disease of pregnancy (HDP) with moderate-severe bronchopulmonary dysplasia (BPD) in preterm infants (< 31 weeks' gestation).

Study design: Preterm birth cohort study of 693 mother-infant dyads. Severe HDP was defined as severe preeclampsia, HELLP syndrome or eclampsia. The outcome was moderate-severe BPD classified at 36 weeks corrected gestational age, per the NICHD Consensus statement.

Results: 225 (32%) mothers developed severe HDP and 234 (34%) infants had moderate-severe BPD. There was an interaction between severe HDP and gestational age (p = 0.03). Infants born at < 25 weeks gestation to mothers with HDP had increased odds for moderate-severe BPD compared to infants of normotensive mothers delivering at the same gestational age. Infants born > 28 weeks to mothers with severe HDP had decreased odds for the outcome, though not statistically significant.

Conclusions: Severe HDP has a differential effect on the development of moderate-severe BPD based on gestational age.

MeSH terms

  • Adult
  • Bronchopulmonary Dysplasia* / complications
  • Cohort Studies
  • Female
  • Gestational Age*
  • Humans
  • Hypertension, Pregnancy-Induced*
  • Infant, Newborn
  • Infant, Premature*
  • Logistic Models
  • Male
  • Pre-Eclampsia
  • Pregnancy
  • Risk Factors
  • Severity of Illness Index