Leg ulcers are indicators of systemic dysfunction in individuals with sickle cell disease

Tiffany A Jackson; Ashley J Buscetta; Hasmin C Ramirez; Vence L Bonham Jr; Caterina P Minniti

doi:10.1002/ajh.27250

Leg ulcers are indicators of systemic dysfunction in individuals with sickle cell disease

Am J Hematol. 2024 Apr;99(4):767-769. doi: 10.1002/ajh.27250. Epub 2024 Mar 3.

Authors

Tiffany A Jackson¹, Ashley J Buscetta¹, Hasmin C Ramirez¹, Vence L Bonham Jr¹, Caterina P Minniti²

Affiliations

¹ Health Disparities Unit, Social and Behavioral Research Branch, National Human Genome Research Institute, Bethesda, Maryland, USA.
² Department of Medicine, Einstein College of Medicine, Bronx, New York, USA.

PMID: 38433376
PMCID: PMC10979399 (available on 2025-04-01)
DOI: 10.1002/ajh.27250

Abstract

Leg ulcers in individuals living with Sickle Cell Disease are evidence of systemic dysfunction. Data from a U.S. study link leg ulcers to wider pulse pressure and markers of chronic hemolysis, inflammation, renal, and liver dysfunction.

Publication types

Letter
Research Support, N.I.H., Intramural

MeSH terms

Anemia, Sickle Cell* / complications
Blood Pressure
Hemolysis
Humans
Inflammation
Leg Ulcer* / etiology

Abstract

Publication types

MeSH terms

Grants and funding