Feeding two birds with one scone: The dual roles of SMARCAL1 in antitumor immunity

Eléonore Toufektchan; John Maciejowski

doi:10.1016/j.molcel.2024.02.009

Feeding two birds with one scone: The dual roles of SMARCAL1 in antitumor immunity

Mol Cell. 2024 Mar 7;84(5):819-821. doi: 10.1016/j.molcel.2024.02.009.

Authors

Eléonore Toufektchan¹, John Maciejowski²

Affiliations

¹ Molecular Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
² Molecular Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address: [email protected].

PMID: 38458172
DOI: 10.1016/j.molcel.2024.02.009

Abstract

In a recent issue of Cell, Leuzzi et al.¹ report the identification of the DNA translocase SMARCAL1 as a novel factor that dampens immune responses against tumor cells through two distinct mechanisms.

MeSH terms

DNA
Neoplasms* / immunology

Substances

DNA
SMARCAL1 protein, human