A20: a jack of all trades

Pieter Hertens; Geert van Loo

doi:10.1016/j.tcb.2024.02.008

A20: a jack of all trades

Trends Cell Biol. 2024 May;34(5):360-362. doi: 10.1016/j.tcb.2024.02.008. Epub 2024 Mar 9.

Authors

Pieter Hertens¹, Geert van Loo²

Affiliations

¹ VIB Center for Inflammation Research, 9052 Ghent, Belgium; Department of Biomedical Molecular Biology, Ghent University, 9052 Ghent, Belgium.
² VIB Center for Inflammation Research, 9052 Ghent, Belgium; Department of Biomedical Molecular Biology, Ghent University, 9052 Ghent, Belgium. Electronic address: [email protected].

PMID: 38461099
DOI: 10.1016/j.tcb.2024.02.008

Abstract

Mutations and polymorphisms in A20/TNFAIP3 have been linked to various inflammatory disorders. However, in addition to its well-known role in inflammation, A20 also controls EDAR- and receptor activator of NF-κB (RANK)-induced NF-κB signaling, regulating the development of epidermal skin appendages and bone, respectively. Furthermore, A20 regulates synapse remodeling through a mechanism dependent on NF-κB.

Keywords: A20; EDAR; NF-κB; RANK; development; synapse.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Edar Receptor / metabolism
Humans
Inflammation / metabolism
Inflammation / pathology
Intracellular Signaling Peptides and Proteins / metabolism
NF-kappa B* / metabolism
Receptor Activator of Nuclear Factor-kappa B / metabolism
Signal Transduction*
Tumor Necrosis Factor alpha-Induced Protein 3* / metabolism

Substances

Edar Receptor
Intracellular Signaling Peptides and Proteins
NF-kappa B
Receptor Activator of Nuclear Factor-kappa B
TNFAIP3 protein, human
Tumor Necrosis Factor alpha-Induced Protein 3