FCRL3 expression is upregulated and closely correlates with TIGIT expression in regulatory T cells of patients with systemic lupus erythematosus

Eur J Immunol. 2024 May;54(5):e2350739. doi: 10.1002/eji.202350739. Epub 2024 Mar 10.

Abstract

Using data from single-cell RNA sequencing and flow cytometry, we initially examined the expression of FCRL3, finding it to be elevated and positively associated with TIGIT expression in the regulatory T cells of patients with systemic lupus erythematosus. This also suggests that the co-expression of FCRL3 and TIGIT warrants further attention.

Keywords: FCRL3; TIGIT; Treg; systemic lupus erythematosus.

Publication types

  • Research Support, Non-U.S. Gov't
  • Letter

MeSH terms

  • Adult
  • Female
  • Humans
  • Lupus Erythematosus, Systemic* / genetics
  • Lupus Erythematosus, Systemic* / immunology
  • Male
  • Receptors, Immunologic* / genetics
  • Receptors, Immunologic* / metabolism
  • T-Lymphocytes, Regulatory* / immunology
  • Up-Regulation / immunology

Substances

  • Receptors, Immunologic
  • TIGIT protein, human
  • FCRL3 protein, human