An inside job: New roles for ApoE at the lipid droplet

J Cell Biol. 2024 Apr 1;223(4):e202402171. doi: 10.1083/jcb.202402171. Epub 2024 Mar 11.

Abstract

The secreted ApoE protein is a major regulator of lipid transport between brain cells. In this issue, Windham et al. (https://doi.org/10.1083/jcb.202305003) uncover a novel intracellular role for ApoE at the lipid droplet surface, where it regulates lipid droplet size and composition.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Animals
  • Apolipoproteins E* / metabolism
  • Biological Transport
  • Humans
  • Lipid Droplets* / metabolism

Substances

  • Apolipoproteins E