Reduced incretin effect precedes diabetes development following duodenopancreatectomy in individuals without diabetes

J Clin Invest. 2024 Mar 12;134(8):e175133. doi: 10.1172/JCI175133.

Gianfranco Di Giuseppe^{1

2}, Laura Soldovieri^{1

2}, Gea Ciccarelli^{1

2}, Pietro Manuel Ferraro³, Giuseppe Quero^{2

4}, Francesca Cinti^{1

2}, Umberto Capece^{1

2}, Simona Moffa^{1

2}, Enrico Celestino Nista^{2

5}, Antonio Gasbarrini^{2

5}, Andrea Mari⁶, Sergio Alfieri^{2

4}, Vincenzo Tondolo⁷, Alfredo Pontecorvi², Jens Juul Holst⁸, Andrea Giaccari^{1

2}, Teresa Mezza^{2

5}

¹ Centre for Endocrine and Metabolic Diseases, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.
² Dipartimento di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, Rome, Italy.
³ Sezione di Nefrologia - Università di Verona, Verona, Italy.
⁴ Digestive Surgery Unit and.
⁵ Pancreas Unit, CEMAD, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.
⁶ Institute of Neuroscience, National Research Council of Italy, Padua, Italy.
⁷ Digestive Surgery Unit, Ospedale Isola Tiberina - Gemelli Isola, Rome, Italy.
⁸ Novo Nordisk Foundation Centre for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.

No abstract available

Keywords: Beta cells; Diabetes; Endocrinology; Glucose metabolism; Metabolism.

MeSH terms