Ginkgolides with anti-PAF activity from Ginkgo biloba L

Fitoterapia. 2024 Jun:175:105915. doi: 10.1016/j.fitote.2024.105915. Epub 2024 Mar 19.

Abstract

Four undescribed ginkgolides, including two rare sesquiterpene ginkgolides (compounds 1 and 2) and two diterpenoid ginkgolides (compounds 3 and 4), were isolated from Ginkgo biloba L. The structures of these four ginkgolides were identified based on extensive spectroscopic analysis, DP4+ probability analysis and X-ray diffraction. Compounds 1 and 2 exhibited excellent antiplatelet aggregation activities with IC50 values of 1.20 ± 0.25 and 4.11 ± 0.34 μM, respectively.

Keywords: Antiplatelet aggregation activities; Ginkgo biloba; Ginkgolides.

MeSH terms

  • Animals
  • Ginkgo biloba* / chemistry
  • Ginkgolides* / chemistry
  • Ginkgolides* / isolation & purification
  • Ginkgolides* / pharmacology
  • Molecular Structure
  • Phytochemicals* / isolation & purification
  • Phytochemicals* / pharmacology
  • Platelet Aggregation / drug effects
  • Platelet Aggregation Inhibitors* / chemistry
  • Platelet Aggregation Inhibitors* / isolation & purification
  • Platelet Aggregation Inhibitors* / pharmacology

Substances

  • Ginkgolides
  • Platelet Aggregation Inhibitors
  • Phytochemicals