Noninvasive Stereotactic Radiotherapy for PADN in an Acute Canine Model of Pulmonary Arterial Hypertension

Wei Xu; Ding-Yu Wang; Zi-Yin Chen; Qiang Gao; Yi-Lun Zou; Dang-Hui Sun; Song Zhang; Xin-Bo Zhao; Yong-Tai Gong; Yun Zhang; Da-Xin Zhang; Yue Li

doi:10.1016/j.jacbts.2023.09.013

Noninvasive Stereotactic Radiotherapy for PADN in an Acute Canine Model of Pulmonary Arterial Hypertension

JACC Basic Transl Sci. 2023 Dec 6;9(2):244-256. doi: 10.1016/j.jacbts.2023.09.013. eCollection 2024 Feb.

Authors

Wei Xu¹, Ding-Yu Wang¹, Zi-Yin Chen², Qiang Gao¹, Yi-Lun Zou¹, Dang-Hui Sun¹, Song Zhang¹, Xin-Bo Zhao¹, Yong-Tai Gong¹, Yun Zhang¹, Da-Xin Zhang², Yue Li^{1

3

4

5

6}

Affiliations

¹ Department of Cardiology, the First Affiliated Hospital, Harbin Medical University, Harbin, China.
² Department of Oncology, the First Affiliated Hospital, Harbin Medical University, Harbin, China.
³ National Key Laboratory of Frigid Zone Cardiovascular Diseases, Harbin Medical University, Harbin, China.
⁴ NHC Key Laboratory of Cell Transplantation, Harbin Medical University, Harbin, Heilongjiang Province, China.
⁵ Institute of Metabolic Disease, Heilongjiang Academy of Medical Science, Harbin, China.
⁶ Heilongjiang Province Clinical Medical Research Center for Hypertension, the First Affiliated Hospital, Harbin Medical University, Harbin, China.

Abstract

This study assesses the feasibility, safety, and effectiveness of noninvasive stereotactic body radiotherapy (SBRT) as an approach for pulmonary artery denervation in canine models. SBRT with CyberKnife resulted in reduced mean pulmonary artery pressure, pulmonary capillary wedge pressure, and pulmonary vascular resistance, and insignificantly increased cardiac output. In comparison to the control group, serum norepinephrine levels at 1 month and 6 months were significantly lower in the CyberKnife group. Computed tomography, pulmonary angiography, and histology analysis revealed that SBRT was associated with minimal collateral damage.

Keywords: noninvasive stereotactic body radiotherapy; pulmonary arterial hypertension; pulmonary artery; pulmonary artery denervation.