A SIFI odyssey: Silencing the stress response amid mitochondrial import blockade to safeguard cell survival

Yuleika G Martinez Castillo; Chantell S Evans

doi:10.1016/j.molcel.2024.02.034

A SIFI odyssey: Silencing the stress response amid mitochondrial import blockade to safeguard cell survival

Mol Cell. 2024 Mar 21;84(6):1000-1002. doi: 10.1016/j.molcel.2024.02.034.

Authors

Yuleika G Martinez Castillo¹, Chantell S Evans²

Affiliations

¹ Department of Cell Biology, Duke University School of Medicine, Durham, NC 27701, USA.
² Department of Cell Biology, Duke University School of Medicine, Durham, NC 27701, USA. Electronic address: [email protected].

PMID: 38518747
DOI: 10.1016/j.molcel.2024.02.034

Abstract

In a recent study in Nature, Haakonsen et al.¹ identify the SIFI complex as a stress response silencer via its E3 ligase activity to target unimported mitochondrial proteins and stress response components for degradation via the proteasome.

MeSH terms

Cell Survival
Mitochondria* / genetics
Mitochondria* / metabolism
Mitochondrial Proteins / genetics
Mitochondrial Proteins / metabolism
Proteasome Endopeptidase Complex* / metabolism
Ubiquitin-Protein Ligases / genetics
Ubiquitin-Protein Ligases / metabolism
Ubiquitination

Substances

Proteasome Endopeptidase Complex
Mitochondrial Proteins
Ubiquitin-Protein Ligases