Effects of Shock and Vibration on Product Quality during Last-Mile Transportation of Ebola Vaccine under Refrigerated Conditions1

Emerg Infect Dis. 2024 Apr;30(4):757-760. doi: 10.3201/eid3004.231060.

Abstract

Analyzing vaccine stability under different storage and transportation conditions is critical to ensure that effectiveness and safety are not affected by distribution. In a simulation of the last mile in the supply chain, we found that shock and vibration had no effect on Ad26.ZEBOV/MVA-BN-Filo Ebola vaccine regimen quality under refrigerated conditions.

Keywords: Ebola vaccine; Ebola virus; Ebola virus disease; vaccine potency; vaccines; vibration; viruses.

MeSH terms

  • Antibodies, Viral
  • Computer Simulation
  • Ebola Vaccines*
  • Ebolavirus*
  • Hemorrhagic Fever, Ebola* / prevention & control
  • Humans
  • Vibration

Substances

  • Ebola Vaccines
  • Antibodies, Viral