Photogenerated chlorine radicals activate C(sp3)-H bonds of alkylbenzenes to access quinazolinones

Org Biomol Chem. 2024 Apr 17;22(15):2968-2973. doi: 10.1039/d4ob00129j.

Abstract

An Fe-catalyzed visible-light induced condensation of alkylbenzenes with anthranilamides has been developed. Upon irradiation, the trivalent iron complex could generate chlorine radicals, which successfully abstracted the hydrogen of benzylic C-H bonds to form benzyl radicals. And these benzyl radicals were converted into oxygenated products under air conditions, which subsequently reacted with anthranilamides for the synthesis of quinazolinones.